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WEP-M+2 Project

Rosetta@home

  • Fluorescent proteins designed from scratch

    Veröffentlicht: September 18, 2018, 1:14am CEST


    Congrats to all Rosetta@home volunteers who contributed to a recent report in Nature describing the design of a completely artificial fluorescent beta-barrel protein. As described by one of the main authors, Anastassia, in this forum post:

    The paper presents many “firsts” in computational protein design. It is the first de novo design of the beta-barrel fold (one of the most described folds in the past 35 years, yet mysterious until now). It is also the first de novo design of a protein tailored to bind a small-molecule, which requires very high accuracy in the placement of side chains on protein backbones assembled from scratch. Additionally, we could show that these new proteins could fold and function as expected in vivo! We hope that the advances described in the paper will further enable the de novo design of many biosensors and catalysts tailored for specific applications.

    Thanks to all the Rosetta@home volunteers who contributed to the validation of our designed proteins and binding sites.

    Here is the link to the IPD webpage that contains a copy of the paper. The work was also featured in the news articles below (the news in Science contains a video of one of our proteins glowing in living cells).

    https://www.bakerlab.org/index.php/2018/09/12/de-novo-fluorescent-proteins

    [https:]]
    [www.sciencemag.org]

Acoustics@home: News

  • Report at GRID'2018

    Veröffentlicht: September 15, 2018, 11:38pm CEST
    The report 'Application of BOINC-based volunteer computing for comparison of the geoacoustic inversion algorithms efficiency.' was made in Dubna at the conference GRID'2018. In this report, results obtained in Acoustics@home are discussed. The presentation is available online

    На 8-ой международной конференции GRID'2018 в Дубне был сделан доклад по результатам Acoustics@home.

XANSONS for COD: News

PrimeGrid

  • Oktoberfest Challenge!

    Veröffentlicht: September 15, 2018, 1:03pm CEST
    From September 15th, 2018 Primegrid will be running a Cullen Challenge to celebrate Oktoberfest! The wold's biggest Volkfest is held annually in Munich, Bavaria, Germany, with more than six million people from around the world attending. The 7 day Challenge starts at 18:00 UTC and ends on 22nd September exactly one week later at 18:00 UTC. Work units from the CUL (LLR) project, which are downloaded and completed during the challenge will count towards your challenge score. The last Cullen Prime found was 6679881*2^6679881+1 from 2009. We're now testing numbers past 16M, so emotionally due for a prime. For more information and discussion, please head over to the official challenge thread: [www.primegrid.com] Good luck!

Citizen Science Grid: News

  • [all] status update

    Veröffentlicht: September 11, 2018, 3:07am CEST
    Hi Everyone!

    Sorry for a lot of silence on our end -- things have been quite hectic this summer! I accepted a new position and now am at Rochester Institute of Technology and busily getting a new lab set up (and having some students migrate along with me).

    I'm going to let some of the work units clear out of the system and set up some new runs which should help fix some of the issues you've been seeing with bad workunits. In the longer term, I've started work on an updated binary which should also allow for the use of GPUs, which should hopefully allow the runs to scale a bit better without running into these problems.

    I'll be keeping you posted as that comes along, but right now we're all just trying to get settled in a new place! Thanks again for all your support. The results coming in are definitely interesting ones!

SRBase: News

  • Looking for a compiler

    Veröffentlicht: September 8, 2018, 9:51am CEST
    I have planned a long time ago a new subproject with opencl but cannot compile it with visual studio. If you are able to compile it under windows, linux and mac let me know. The source code can be found here.

    I also need to find out how the app is running with which commands.

BOINC

  • Web site changes

    Veröffentlicht: September 6, 2018, 1:06am CEST
    The BOINC message boards are now in boinc.berkeley.edu/ rather than boinc.berkeley.edu/dev/. This means, among other things, that when you select a language, it applies to both front page and message boards.

    Also, the front page now presents the option of participating using Science United. Current volunteers should consider doing this. By making it easier for new projects to get volunteers, SU will encourage the creation of new BOINC projects.

YAFU: News

MilkyWay@home:

XANSONS for COD: News

SRBase: News

  • base R873 Megaprime

    Veröffentlicht: August 31, 2018, 6:47pm CEST
    And again, on 22th of August, Deltik, a member of the team Gridcoin has found a megaprime 104*873^344135-1 for base R873. The prime has 1.012.108 digits and entered the TOP5000 in Chris Caldwell's The Largest Known Primes Database.

    Well done!

BOINC

MilkyWay@home:

  • Database Maintenance

    Veröffentlicht: August 30, 2018, 7:34pm CEST
    Hello Everyone.
    I am Jeff Thompson and have been working on and off with MilkyWay@home since 2012, but I have been quiet recently.

    For the next few months, on Tuesdays, we will be scheduling server maintenance.
    We will post on the day threads for any issues that may arise.

    This is a heads up.

    Thank you for your continued support.

YAFU: News

SRBase: News

  • base R978 Megaprime

    Veröffentlicht: August 28, 2018, 7:47pm CEST
    On 19th of August, Deltik, a member of the team Gridcoin has found a megaprime 164*978^387920-1 for base R978. The prime has 1.160.015 digits and entered the TOP5000 in Chris Caldwell's The Largest Known Primes Database.

    Well done!

YAFU: News

PrimeGrid

  • New SR5 Mega Prime!

    Veröffentlicht: August 22, 2018, 3:51pm CEST
    On 15 August 2018, 03:15:13 UTC, PrimeGrid’s Sierpinski/Riesel Base 5 Problem project eliminated k=194368 by finding the mega prime: 194368*5^2638045-1 The prime is 1,843,920 digits long and will enter Chris Caldwell's The Largest Known Primes Database ranked 60th overall and is the largest known base 5 prime. 69 k's now remain in the Riesel Base 5 Problem. The discovery was made by Honza Cholt (Honza) of the Czech Republic using an Intel(R) Core(TM) i7-8700K CPU @ 3.70GHz with 20 GB RAM running Microsoft Windows Server 2016. This computer took about 4 hours 44 minutes to complete the primality test using multithreaded LLR. Honza is a member of the Czech National Team. The prime was verified on 17 August 2018, 10:15:20 UTC by Deano Montreuil (Deano Montreuil) of the United States using an Intel(R) Core(TM) i5-2400 CPU @ 3.10GHz with 8 GB RAM running Microsoft Windows 10 Core Edition. This computer took about 61 hours 55 minutes to complete the primality test using LLR. Deano is a member of the Aggie The Pew team. For more details, please see the official announcement.

MilkyWay@home:

  • New MilkyWay@Home Developer

    Veröffentlicht: August 21, 2018, 7:42pm CEST
    Hello all,

    My name is Eric Mendelsohn, and I am a new developer working on the code for MilkyWay@Home. I am currently working on testing the impact of several parameters implicit within the N-body integrator used in MilkyWay@Home. I am also working on adding new gravitational potential models for the simulated bulge, disk, and halo of the Milky Way Galaxy. If you have any questions involving N-body, I will do my best to answer them as accurately as possible.

    Thank you for your support!
  • New Separation Runs

    Veröffentlicht: August 21, 2018, 4:14pm CEST
    Hey Everyone,

    I put up a few new separation runs. You may notice that these have slightly different run times. The credit awarded should reflect the run time.

    The run names are:

    de_modfit_sim19fixed_bundle4_4s_NoContraintsWithDisk260_1
    de_modfit_sim19fixed_bundle4_4s_NoContraintsWithDisk260_2
    de_modfit_sim19fixed_bundle4_4s_NoContraintsWithDisk260_3
    de_modfit_sim19fixed_bundle6_2s_NoContraintsWithDisk140_1
    de_modfit_sim19fixed_bundle6_2s_NoContraintsWithDisk140_2
    de_modfit_sim19fixed_bundle6_2s_NoContraintsWithDisk140_3

    If you have any questions or issues, let me know.

    Jake